Gen Sobue Selected Research

Superoxide Dismutase-1

10/2016	Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis.
1/2011	Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease.
1/2011	High-Resolution Melting (HRM) Analysis of the Cu/Zn Superoxide Dismutase (SOD1) Gene in Japanese Sporadic Amyotrophic Lateral Sclerosis (SALS) Patients.
1/2010	Familial amyotrophic lateral sclerosis with a novel G85S mutation of superoxide dismutase 1 gene: clinical features of lower motor neuron disease.
8/2008	A strategy for developing effective amyotropic lateral sclerosis pharmacotherapy: from clinical trials to novel pharmacotherapeutic strategies.
9/2007	Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.
8/2006	Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.
5/2006	Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70.
1/2006	Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA.
12/2004	Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.

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Gen Sobue Research Topics

Disease

84	X-Linked Bulbo-Spinal Atrophy 01/2022 - 08/2002
55	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2022 - 01/2002
39	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 12/2002
37	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2020 - 03/2003
26	Parkinson Disease (Parkinson's Disease) 12/2021 - 06/2005
22	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/2022 - 04/2002
22	Polyneuropathies (Polyneuropathy) 01/2022 - 04/2002
17	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 04/2021 - 03/2012
16	Disease Progression 01/2022 - 05/2006
15	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 12/2018 - 11/2002
15	Atrophy 11/2018 - 06/2005
12	Alzheimer Disease (Alzheimer's Disease) 05/2022 - 08/2002
12	Muscle Weakness 03/2018 - 06/2006
11	Pain (Aches) 01/2018 - 11/2003
10	Muscular Atrophy (Muscle Atrophy) 01/2020 - 11/2005
9	Demyelinating Diseases (Demyelinating Disease) 02/2021 - 11/2010
9	Neuromuscular Diseases (Neuromuscular Disease) 01/2020 - 01/2015
9	Neoplasms (Cancer) 01/2015 - 08/2006
8	Orthostatic Hypotension (Postural Hypotension) 12/2018 - 06/2010
7	Inflammation (Inflammations) 03/2022 - 11/2002
7	Dementia (Dementias) 01/2021 - 05/2003
6	Churg-Strauss Syndrome (Allergic Angiitis) 03/2022 - 10/2013
6	Deglutition Disorders (Dysphagia) 01/2022 - 06/2006
6	Paraproteinemias (Monoclonal Gammopathy) 12/2020 - 01/2015
6	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 05/2014
6	Huntington Disease (Huntington's Disease) 01/2020 - 06/2004
6	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2020 - 06/2004
6	Amyloidosis 12/2018 - 12/2009
6	Thiamine Deficiency 03/2015 - 07/2003
5	Nervous System Heredodegenerative Disorders 01/2022 - 11/2006
5	Frontotemporal Dementia (Semantic Dementia) 01/2020 - 08/2009
5	Peripheral Nervous System Diseases (PNS Diseases) 01/2017 - 06/2011
4	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 05/2022 - 11/2004
4	Microscopic Polyangiitis 03/2022 - 10/2013
4	Cognitive Dysfunction 01/2020 - 06/2014
4	Speech Disorders (Cluttering) 01/2020 - 05/2015
4	Dysarthria (Spastic Dysarthria) 12/2019 - 06/2006
3	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 03/2022 - 10/2013
3	Necrosis 01/2021 - 09/2010
3	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 01/2020 - 05/2008
3	Vasculitis (Vasculitides) 01/2020 - 10/2015
3	Stroke (Strokes) 01/2020 - 01/2016
3	Transthyretin-Related Hereditary Amyloidosis 01/2019 - 11/2011
3	Headache (Headaches) 01/2018 - 01/2009
3	Voice Disorders (Voice Disturbances) 12/2017 - 08/2015
3	Alcoholism (Alcohol Abuse) 01/2017 - 07/2012

Drug/Important Bio-Agent (IBA)

57	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 08/2002
52	polyglutamineIBA 01/2022 - 08/2002
34	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
19	Intravenous Immunoglobulins (IVIG)FDA Link 01/2019 - 11/2005
17	Prealbumin (Transthyretin)IBA 12/2018 - 04/2002
14	Superoxide Dismutase-1IBA 10/2016 - 08/2002
12	Amyloid (Amyloid Fibrils)IBA 05/2022 - 12/2009
12	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2012
12	AndrogensIBA 01/2022 - 04/2007
11	DNA-Binding Proteins (DNA Binding Protein)IBA 04/2021 - 08/2009
11	AntibodiesIBA 12/2020 - 02/2011
10	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2013
9	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 11/2002
8	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 02/2014
8	Immunoglobulin G (IgG)IBA 12/2020 - 04/2013
8	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2020 - 01/2013
7	HizentraIBA 01/2022 - 01/2016
7	Leuprolide (Lupron)FDA LinkGeneric 01/2022 - 06/2003
7	UbiquitinIBA 01/2021 - 11/2002
7	3-Iodobenzylguanidine (Iobenguane)IBA 12/2018 - 12/2007
7	Messenger RNA (mRNA)IBA 07/2015 - 04/2002
6	Pharmaceutical PreparationsIBA 01/2022 - 09/2010
6	Testosterone (Sustanon)FDA Link 01/2022 - 08/2002
6	Immunoglobulin M (IgM)IBA 12/2020 - 09/2010
5	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 03/2022 - 09/2010
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2012
5	Myelin-Associated GlycoproteinIBA 12/2020 - 09/2010
5	AutoantibodiesIBA 12/2018 - 10/2011
5	Thiamine (Aneurin)FDA Link 03/2015 - 11/2004
5	Prion ProteinsIBA 12/2009 - 06/2005
4	Acetates (Acetic Acid Esters)FDA Link 01/2022 - 08/2009
4	Nerve Growth Factors (Neurotrophins)IBA 01/2020 - 04/2002
4	Levodopa (L Dopa)FDA LinkGeneric 06/2019 - 01/2008
4	Biological ProductsIBA 01/2018 - 07/2013
4	Protein Isoforms (Isoforms)IBA 01/2018 - 12/2012
4	CreatinineIBA 01/2018 - 09/2012
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 08/2003
4	Folic Acid (Vitamin M)FDA LinkGeneric 01/2017 - 07/2012
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2016 - 03/2004
4	alpha-SynucleinIBA 01/2014 - 08/2003
4	CytokinesIBA 04/2012 - 04/2002
4	Codon (Codons)IBA 01/2010 - 11/2006
4	Mutant Proteins (Protein, Mutant)IBA 12/2009 - 08/2006
3	Sodium Channels (Sodium Channel)IBA 12/2020 - 11/2015
3	Complement System Proteins (Complement)IBA 01/2020 - 11/2010
3	Fingolimod Hydrochloride (FTY720)FDA Link 01/2018 - 08/2016

Therapy/Procedure

46	Therapeutics 01/2022 - 08/2003
8	Deep Brain Stimulation 12/2021 - 01/2013
8	Activities of Daily Living (ADL) 06/2019 - 06/2006
8	Molecular Targeted Therapy 07/2012 - 08/2006
4	Stem Cell Transplantation 08/2021 - 01/2006
4	Sympathectomy (Sympathectomies) 04/2014 - 12/2007
4	Liver Transplantation 11/2013 - 11/2011
3	Tracheostomy 01/2022 - 06/2015